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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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World-2DPAGE Portal
World-2DPAGE Repository
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Searching in 'USC-OGP 2-DE database' for entry
matching:
P28482
USC-OGP 2-DE database
:
P28482
P28482
General information about the entry
View entry in simple text format
Entry name
MK01_HUMAN
Primary accession number
P28482
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Mitogen-activated protein kinase 1; Short=MAP kinase 1; Short=MAPK 1; EC=2.7.11.24; AltName: Full=ERT1; AltName: Full=Extracellular signal-regulated kinase 2; Short=ERK-2; AltName: Full=MAP kinase isoform p42; Short=p42-MAPK; AltName: Full=Mitogen-activated protein kinase 2; Short=MAP kinase 2; Short=MAPK 2;.
Gene name
Name=MAPK1
Synonyms=ERK2, PRKM1, PRKM2
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_4-7
{PLATELET 4-7}
Homo sapiens (Human)
map experimental info
PLATELET_4-7
MAP LOCATIONS:
SPOT OGP-0433
:
pI=6.49; Mw=40117
Cross-references
UniProtKB/Swiss-Prot
P28482; MK01_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
MK01_HUMAN
Primary accession number
P28482
Secondary accession number(s)
A8CZ64
Sequence was last modified on
January 23, 2007 (version 3)
Annotations were last modified on
March 15, 2017 (version 200)
Name and origin of the protein
Description
RecName: Full=Mitogen-activated protein kinase 1; Short=MAP kinase 1; Short=MAPK 1; EC=2.7.11.24; AltName: Full=ERT1; AltName: Full=Extracellular signal-regulated kinase 2; Short=ERK-2; AltName: Full=MAP kinase isoform p42; Short=p42-MAPK; AltName: Full=Mitogen-activated protein kinase 2; Short=MAP kinase 2; Short=MAPK 2;
Gene name
Name=MAPK1
Synonyms=ERK2, PRKM1, PRKM2
Encoded on
Name=MAPK1; Synonyms=ERK2, PRKM1, PRKM2
Keywords
3D-structure
;
Acetylation
;
Alternative splicing
;
Apoptosis
;
ATP-binding
;
Cell cycle
;
Complete proteome
;
Cytoplasm
;
Cytoskeleton
;
Direct protein sequencing
;
DNA-binding
;
Host-virus interaction
;
Kinase
;
Nucleotide-binding
;
Nucleus
;
Phosphoprotein
;
Reference proteome
;
Repressor
;
Serine/threonine-protein kinase
;
Transcription
;
Transcription regulation
;
Transferase
;
Ubl conjugation
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
M84489; AAA58459.1
; -; mRNA
EMBL
Z11694; CAA77752.1
; -; mRNA
EMBL
Z11695; CAA77753.1
; ALT_INIT; mRNA
EMBL
DQ399292; ABD60303.1
; -; mRNA
EMBL
AP000553; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
AP000554; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
AP000555; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
BC017832; AAH17832.1
; -; mRNA
CCDS
CCDS13795.1; -. [P28482-1]
; .
PIR
JQ1400; JQ1400
; .
RefSeq
NP_002736.3; NM_002745.4. [P28482-1]
; .
RefSeq
NP_620407.1; NM_138957.3. [P28482-1]
; .
UniGene
Hs.431850; -
; .
PDB
1PME; X-ray
; 2.00 A; A=1-360
PDB
1TVO; X-ray
; 2.50 A; A=1-360
PDB
1WZY; X-ray
; 2.50 A; A=1-360
PDB
2OJG; X-ray
; 2.00 A; A=2-360
PDB
2OJI; X-ray
; 2.60 A; A=2-360
PDB
2OJJ; X-ray
; 2.40 A; A=2-360
PDB
2Y9Q; X-ray
; 1.55 A; A=1-360
PDB
3D42; X-ray
; 2.46 A; B=184-191
PDB
3D44; X-ray
; 1.90 A; B=184-191
PDB
3I5Z; X-ray
; 2.20 A; A=1-360
PDB
3I60; X-ray
; 2.50 A; A=1-360
PDB
3SA0; X-ray
; 1.59 A; A=1-360
PDB
3TEI; X-ray
; 2.40 A; A=1-360
PDB
3W55; X-ray
; 3.00 A; A=1-360
PDB
4FMQ; X-ray
; 2.10 A; A=1-360
PDB
4FUX; X-ray
; 2.20 A; A=1-360
PDB
4FUY; X-ray
; 2.00 A; A=1-360
PDB
4FV0; X-ray
; 2.10 A; A=1-360
PDB
4FV1; X-ray
; 1.99 A; A=1-360
PDB
4FV2; X-ray
; 2.00 A; A=1-360
PDB
4FV3; X-ray
; 2.20 A; A=1-360
PDB
4FV4; X-ray
; 2.50 A; A=1-360
PDB
4FV5; X-ray
; 2.40 A; A=1-360
PDB
4FV6; X-ray
; 2.50 A; A=1-360
PDB
4FV7; X-ray
; 1.90 A; A=1-360
PDB
4FV8; X-ray
; 2.00 A; A=1-360
PDB
4FV9; X-ray
; 2.11 A; A=1-360
PDB
4G6N; X-ray
; 2.00 A; A=1-360
PDB
4G6O; X-ray
; 2.20 A; A=1-360
PDB
4H3P; X-ray
; 2.30 A; A/D=1-360
PDB
4H3Q; X-ray
; 2.20 A; A=1-360
PDB
4IZ5; X-ray
; 3.19 A; A/B/C/D=8-360
PDB
4IZ7; X-ray
; 1.80 A; A/C=8-360
PDB
4IZA; X-ray
; 1.93 A; A/C=8-360
PDB
4N0S; X-ray
; 1.80 A; A=1-360
PDB
4NIF; X-ray
; 2.15 A; B/E=1-360
PDB
4O6E; X-ray
; 1.95 A; A=13-360
PDB
4QP1; X-ray
; 2.70 A; A/B=1-360
PDB
4QP2; X-ray
; 2.23 A; A/B=1-360
PDB
4QP3; X-ray
; 2.60 A; A/B=1-360
PDB
4QP4; X-ray
; 2.20 A; A/B=1-360
PDB
4QP6; X-ray
; 3.10 A; A/B=1-360
PDB
4QP7; X-ray
; 2.25 A; A/B=1-360
PDB
4QP8; X-ray
; 2.45 A; A/B=1-360
PDB
4QP9; X-ray
; 2.00 A; A=1-360
PDB
4QPA; X-ray
; 2.85 A; A/B=1-360
PDB
4QTA; X-ray
; 1.45 A; A=1-360
PDB
4QTE; X-ray
; 1.50 A; A=1-360
PDB
4XJ0; X-ray
; 2.58 A; A/B=12-360
PDB
4ZXT; X-ray
; 2.00 A; A=1-360
PDB
4ZZM; X-ray
; 1.89 A; A=11-360
PDB
4ZZN; X-ray
; 1.33 A; A=11-360
PDB
4ZZO; X-ray
; 1.63 A; A=11-360
PDB
5AX3; X-ray
; 2.98 A; A=1-360
PDB
5BUE; X-ray
; 2.40 A; A=2-360
PDB
5BUI; X-ray
; 2.12 A; A=2-360
PDB
5BUJ; X-ray
; 1.85 A; A=2-360
PDB
5BVD; X-ray
; 1.90 A; A=2-360
PDB
5BVE; X-ray
; 2.00 A; A=2-360
PDB
5BVF; X-ray
; 1.90 A; A=2-360
PDB
5K4I; X-ray
; 1.76 A; A=9-360
PDB
5LCJ; X-ray
; 1.78 A; A=1-360
PDB
5LCK; X-ray
; 1.89 A; A=1-360
PDBsum
1PME; -
; .
PDBsum
1TVO; -
; .
PDBsum
1WZY; -
; .
PDBsum
2OJG; -
; .
PDBsum
2OJI; -
; .
PDBsum
2OJJ; -
; .
PDBsum
2Y9Q; -
; .
PDBsum
3D42; -
; .
PDBsum
3D44; -
; .
PDBsum
3I5Z; -
; .
PDBsum
3I60; -
; .
PDBsum
3SA0; -
; .
PDBsum
3TEI; -
; .
PDBsum
3W55; -
; .
PDBsum
4FMQ; -
; .
PDBsum
4FUX; -
; .
PDBsum
4FUY; -
; .
PDBsum
4FV0; -
; .
PDBsum
4FV1; -
; .
PDBsum
4FV2; -
; .
PDBsum
4FV3; -
; .
PDBsum
4FV4; -
; .
PDBsum
4FV5; -
; .
PDBsum
4FV6; -
; .
PDBsum
4FV7; -
; .
PDBsum
4FV8; -
; .
PDBsum
4FV9; -
; .
PDBsum
4G6N; -
; .
PDBsum
4G6O; -
; .
PDBsum
4H3P; -
; .
PDBsum
4H3Q; -
; .
PDBsum
4IZ5; -
; .
PDBsum
4IZ7; -
; .
PDBsum
4IZA; -
; .
PDBsum
4N0S; -
; .
PDBsum
4NIF; -
; .
PDBsum
4O6E; -
; .
PDBsum
4QP1; -
; .
PDBsum
4QP2; -
; .
PDBsum
4QP3; -
; .
PDBsum
4QP4; -
; .
PDBsum
4QP6; -
; .
PDBsum
4QP7; -
; .
PDBsum
4QP8; -
; .
PDBsum
4QP9; -
; .
PDBsum
4QPA; -
; .
PDBsum
4QTA; -
; .
PDBsum
4QTE; -
; .
PDBsum
4XJ0; -
; .
PDBsum
4ZXT; -
; .
PDBsum
4ZZM; -
; .
PDBsum
4ZZN; -
; .
PDBsum
4ZZO; -
; .
PDBsum
5AX3; -
; .
PDBsum
5BUE; -
; .
PDBsum
5BUI; -
; .
PDBsum
5BUJ; -
; .
PDBsum
5BVD; -
; .
PDBsum
5BVE; -
; .
PDBsum
5BVF; -
; .
PDBsum
5K4I; -
; .
PDBsum
5LCJ; -
; .
PDBsum
5LCK; -
; .
ProteinModelPortal
P28482; -
; .
SMR
P28482; -
; .
BioGrid
111580; 227
; .
DIP
DIP-519N; -
; .
IntAct
P28482; 84
; .
MINT
MINT-144006; -
; .
STRING
9606.ENSP00000215832; -
; .
BindingDB
P28482; -
; .
ChEMBL
CHEMBL4040; -
; .
DrugBank
DB07264; (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
; .
DrugBank
DB08521; 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
; .
DrugBank
DB08513; [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
; .
DrugBank
DB01169; Arsenic trioxide
; .
DrugBank
DB01064; Isoprenaline
; .
DrugBank
DB07010; N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
; .
DrugBank
DB02116; Olomoucine
; .
DrugBank
DB02482; Phosphonothreonine
; .
DrugBank
DB02733; Purvalanol
; .
DrugBank
DB04338; SB220025
; .
GuidetoPHARMACOLOGY
1495; -
; .
iPTMnet
P28482; -
; .
PhosphoSitePlus
P28482; -
; .
SwissPalm
P28482; -
; .
BioMuta
MAPK1; -
; .
DMDM
119554; -
; .
OGP
P28482; -
; .
EPD
P28482; -
; .
PaxDb
P28482; -
; .
PeptideAtlas
P28482; -
; .
PRIDE
P28482; -
; .
DNASU
5594; -
; .
Ensembl
ENST00000215832; ENSP00000215832
; ENSG00000100030. [P28482-1]; .
Ensembl
ENST00000398822; ENSP00000381803
; ENSG00000100030. [P28482-1]; .
Ensembl
ENST00000544786; ENSP00000440842
; ENSG00000100030. [P28482-2]; .
GeneID
5594; -
; .
KEGG
hsa:5594; -
; .
UCSC
uc010gtk.2; human. [P28482-1]
; .
CTD
5594; -
; .
DisGeNET
5594; -
; .
GeneCards
MAPK1; -
; .
HGNC
HGNC:6871; MAPK1
; .
HPA
CAB004229; -
; .
HPA
HPA003995; -
; .
HPA
HPA005700; -
; .
HPA
HPA030069; -
; .
MalaCards
MAPK1; -
; .
MIM
176948; gene
; .
neXtProt
NX_P28482; -
; .
OpenTargets
ENSG00000100030; -
; .
Orphanet
261330; Distal 22q11.2 microdeletion syndrome
; .
PharmGKB
PA30616; -
; .
eggNOG
KOG0660; Eukaryota
; .
eggNOG
ENOG410XNY0; LUCA
; .
GeneTree
ENSGT00550000074298; -
; .
HOGENOM
HOG000233024; -
; .
HOVERGEN
HBG014652; -
; .
InParanoid
P28482; -
; .
KO
K04371; -
; .
OMA
EEAESHH; -
; .
OrthoDB
EOG091G08QL; -
; .
PhylomeDB
P28482; -
; .
TreeFam
TF105097; -
; .
BRENDA
2.7.11.24; 2681
; .
Reactome
R-HSA-111995; phospho-PLA2 pathway
; .
Reactome
R-HSA-112409; RAF-independent MAPK1/3 activation
; .
Reactome
R-HSA-112411; MAPK1 (ERK2) activation
; .
Reactome
R-HSA-1295596; Spry regulation of FGF signaling
; .
Reactome
R-HSA-162658; Golgi Cisternae Pericentriolar Stack Reorganization
; .
Reactome
R-HSA-198753; ERK/MAPK targets
; .
Reactome
R-HSA-202670; ERKs are inactivated
; .
Reactome
R-HSA-2029482; Regulation of actin dynamics for phagocytic cup formation
; .
Reactome
R-HSA-2559580; Oxidative Stress Induced Senescence
; .
Reactome
R-HSA-2559582; Senescence-Associated Secretory Phenotype (SASP)
; .
Reactome
R-HSA-2559585; Oncogene Induced Senescence
; .
Reactome
R-HSA-2871796; FCERI mediated MAPK activation
; .
Reactome
R-HSA-3371453; Regulation of HSF1-mediated heat shock response
; .
Reactome
R-HSA-375165; NCAM signaling for neurite out-growth
; .
Reactome
R-HSA-437239; Recycling pathway of L1
; .
Reactome
R-HSA-442742; CREB phosphorylation through the activation of Ras
; .
Reactome
R-HSA-444257; RSK activation
; .
Reactome
R-HSA-445144; Signal transduction by L1
; .
Reactome
R-HSA-450341; Activation of the AP-1 family of transcription factors
; .
Reactome
R-HSA-456926; Thrombin signalling through proteinase activated receptors (PARs)
; .
Reactome
R-HSA-5654726; Negative regulation of FGFR1 signaling
; .
Reactome
R-HSA-5654727; Negative regulation of FGFR2 signaling
; .
Reactome
R-HSA-5654732; Negative regulation of FGFR3 signaling
; .
Reactome
R-HSA-5654733; Negative regulation of FGFR4 signaling
; .
Reactome
R-HSA-5663213; RHO GTPases Activate WASPs and WAVEs
; .
Reactome
R-HSA-5673001; RAF/MAP kinase cascade
; .
Reactome
R-HSA-5674135; MAP2K and MAPK activation
; .
Reactome
R-HSA-5674499; Negative feedback regulation of MAPK pathway
; .
Reactome
R-HSA-5675221; Negative regulation of MAPK pathway
; .
Reactome
R-HSA-6798695; Neutrophil degranulation
; .
Reactome
R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants
; .
Reactome
R-HSA-6802948; Signaling by high-kinase activity BRAF mutants
; .
Reactome
R-HSA-6802949; Signaling by RAS mutants
; .
Reactome
R-HSA-6802952; Signaling by BRAF and RAF fusions
; .
Reactome
R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF
; .
Reactome
R-HSA-6811558; PI5P
; PP2A and IER3 Regulate PI3K/AKT Signaling; .
Reactome
R-HSA-74749; Signal attenuation
; .
Reactome
R-HSA-879415; Advanced glycosylation endproduct receptor signaling
; .
Reactome
R-HSA-881907; Gastrin-CREB signalling pathway via PKC and MAPK
; .
Reactome
R-HSA-982772; Growth hormone receptor signaling
; .
SignaLink
P28482; -
; .
SIGNOR
P28482; -
; .
ChiTaRS
MAPK1; human
; .
EvolutionaryTrace
P28482; -
; .
GeneWiki
MAPK1; -
; .
GenomeRNAi
5594; -
; .
PRO
PR:P28482; -
; .
Proteomes
UP000005640; Chromosome 22
; .
Bgee
ENSG00000100030; -
; .
CleanEx
HS_MAPK1; -
; .
ExpressionAtlas
P28482; baseline and differential
; .
Genevisible
P28482; HS
; .
GO
GO:0030424; C:axon
; IEA:Ensembl; .
GO
GO:0035578; C:azurophil granule lumen
; TAS:Reactome; .
GO
GO:0005901; C:caveola
; TAS:UniProtKB; .
GO
GO:0005737; C:cytoplasm
; IDA:UniProtKB; .
GO
GO:0005856; C:cytoskeleton
; TAS:UniProtKB; .
GO
GO:0005829; C:cytosol
; TAS:UniProtKB; .
GO
GO:0032839; C:dendrite cytoplasm
; IEA:Ensembl; .
GO
GO:0005769; C:early endosome
; TAS:UniProtKB; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0005576; C:extracellular region
; TAS:Reactome; .
GO
GO:1904813; C:ficolin-1-rich granule lumen
; TAS:Reactome; .
GO
GO:0005925; C:focal adhesion
; TAS:UniProtKB; .
GO
GO:0005794; C:Golgi apparatus
; TAS:UniProtKB; .
GO
GO:0005770; C:late endosome
; TAS:UniProtKB; .
GO
GO:0005815; C:microtubule organizing center
; IEA:UniProtKB-SubCell; .
GO
GO:0005739; C:mitochondrion
; TAS:UniProtKB; .
GO
GO:0072686; C:mitotic spindle
; ISS:UniProtKB; .
GO
GO:0005654; C:nucleoplasm
; TAS:Reactome; .
GO
GO:0005634; C:nucleus
; IDA:UniProtKB; .
GO
GO:0043204; C:perikaryon
; IEA:Ensembl; .
GO
GO:0043234; C:protein complex
; IEA:Ensembl; .
GO
GO:0031143; C:pseudopodium
; IEA:Ensembl; .
GO
GO:0005524; F:ATP binding
; IEA:UniProtKB-KW; .
GO
GO:0003677; F:DNA binding
; IEA:UniProtKB-KW; .
GO
GO:0042802; F:identical protein binding
; IPI:IntAct; .
GO
GO:0016301; F:kinase activity
; TAS:Reactome; .
GO
GO:0004707; F:MAP kinase activity
; IBA:GO_Central; .
GO
GO:0019902; F:phosphatase binding
; IPI:UniProtKB; .
GO
GO:0004674; F:protein serine/threonine kinase activity
; IDA:UniProtKB; .
GO
GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity
; ISS:UniProtKB; .
GO
GO:0000187; P:activation of MAPK activity
; TAS:Reactome; .
GO
GO:0006915; P:apoptotic process
; TAS:ProtInc; .
GO
GO:0007411; P:axon guidance
; TAS:Reactome; .
GO
GO:0050853; P:B cell receptor signaling pathway
; IEA:Ensembl; .
GO
GO:0060020; P:Bergmann glial cell differentiation
; IEA:Ensembl; .
GO
GO:0061308; P:cardiac neural crest cell development involved in heart development
; IEA:Ensembl; .
GO
GO:0072584; P:caveolin-mediated endocytosis
; TAS:UniProtKB; .
GO
GO:0007049; P:cell cycle
; IEA:UniProtKB-KW; .
GO
GO:0006974; P:cellular response to DNA damage stimulus
; IEA:Ensembl; .
GO
GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus
; IEA:Ensembl; .
GO
GO:0071310; P:cellular response to organic substance
; IBA:GO_Central; .
GO
GO:0007268; P:chemical synaptic transmission
; TAS:ProtInc; .
GO
GO:0006935; P:chemotaxis
; TAS:ProtInc; .
GO
GO:0019858; P:cytosine metabolic process
; IEA:Ensembl; .
GO
GO:0038127; P:ERBB signaling pathway
; IDA:UniProtKB; .
GO
GO:0070371; P:ERK1 and ERK2 cascade
; IDA:UniProtKB; .
GO
GO:0060324; P:face development
; IEA:Ensembl; .
GO
GO:0038095; P:Fc-epsilon receptor signaling pathway
; TAS:Reactome; .
GO
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis
; TAS:Reactome; .
GO
GO:0008543; P:fibroblast growth factor receptor signaling pathway
; TAS:Reactome; .
GO
GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway
; TAS:Reactome; .
GO
GO:0060716; P:labyrinthine layer blood vessel development
; IEA:Ensembl; .
GO
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
; IEA:Ensembl; .
GO
GO:0060291; P:long-term synaptic potentiation
; IEA:Ensembl; .
GO
GO:0060425; P:lung morphogenesis
; IEA:Ensembl; .
GO
GO:0033598; P:mammary gland epithelial cell proliferation
; IEA:Ensembl; .
GO
GO:0000165; P:MAPK cascade
; TAS:Reactome; .
GO
GO:0000189; P:MAPK import into nucleus
; IEA:Ensembl; .
GO
GO:0045596; P:negative regulation of cell differentiation
; IEA:Ensembl; .
GO
GO:0043312; P:neutrophil degranulation
; TAS:Reactome; .
GO
GO:0042473; P:outer ear morphogenesis
; IEA:Ensembl; .
GO
GO:0018105; P:peptidyl-serine phosphorylation
; IDA:BHF-UCL; .
GO
GO:0018107; P:peptidyl-threonine phosphorylation
; ISS:UniProtKB; .
GO
GO:0030168; P:platelet activation
; TAS:Reactome; .
GO
GO:0030335; P:positive regulation of cell migration
; IEA:Ensembl; .
GO
GO:0008284; P:positive regulation of cell proliferation
; IEA:Ensembl; .
GO
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation
; IDA:UniProtKB; .
GO
GO:0051973; P:positive regulation of telomerase activity
; IMP:BHF-UCL; .
GO
GO:1904355; P:positive regulation of telomere capping
; IMP:BHF-UCL; .
GO
GO:0032212; P:positive regulation of telomere maintenance via telomerase
; IMP:BHF-UCL; .
GO
GO:0045893; P:positive regulation of transcription
; DNA-templated; IEA:Ensembl
GO
GO:0045727; P:positive regulation of translation
; IEA:Ensembl; .
GO
GO:0006468; P:protein phosphorylation
; IDA:UniProtKB; .
GO
GO:1900034; P:regulation of cellular response to heat
; TAS:Reactome; .
GO
GO:0051493; P:regulation of cytoskeleton organization
; TAS:UniProtKB; .
GO
GO:2000641; P:regulation of early endosome to late endosome transport
; TAS:UniProtKB; .
GO
GO:0010468; P:regulation of gene expression
; IBA:GO_Central; .
GO
GO:0090170; P:regulation of Golgi inheritance
; TAS:UniProtKB; .
GO
GO:0030278; P:regulation of ossification
; IEA:Ensembl; .
GO
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling
; TAS:Reactome; .
GO
GO:0031647; P:regulation of protein stability
; ISS:UniProtKB; .
GO
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
; TAS:Reactome; .
GO
GO:0032872; P:regulation of stress-activated MAPK cascade
; TAS:UniProtKB; .
GO
GO:0070849; P:response to epidermal growth factor
; IDA:UniProtKB; .
GO
GO:0043627; P:response to estrogen
; IEA:Ensembl; .
GO
GO:0043330; P:response to exogenous dsRNA
; IEA:Ensembl; .
GO
GO:0006950; P:response to stress
; TAS:ProtInc; .
GO
GO:0009636; P:response to toxic substance
; IEA:Ensembl; .
GO
GO:0019233; P:sensory perception of pain
; IEA:Ensembl; .
GO
GO:0007165; P:signal transduction
; TAS:ProtInc; .
GO
GO:0050852; P:T cell receptor signaling pathway
; IEA:Ensembl; .
GO
GO:0048538; P:thymus development
; IEA:Ensembl; .
GO
GO:0030878; P:thyroid gland development
; IEA:Ensembl; .
GO
GO:0060440; P:trachea formation
; IEA:Ensembl; .
GO
GO:0006351; P:transcription
; DNA-templated; IEA:UniProtKB-KW
GO
GO:0016032; P:viral process
; IEA:UniProtKB-KW; .
InterPro
IPR011009; Kinase-like_dom
; .
InterPro
IPR003527; MAP_kinase_CS
; .
InterPro
IPR008349; MAPK_ERK1/2
; .
InterPro
IPR000719; Prot_kinase_dom
; .
InterPro
IPR017441; Protein_kinase_ATP_BS
; .
InterPro
IPR008271; Ser/Thr_kinase_AS
; .
Pfam
PF00069; Pkinase
; 1; .
PRINTS
PR01770; ERK1ERK2MAPK
; .
SMART
SM00220; S_TKc
; 1; .
SUPFAM
SSF56112; SSF56112
; 1; .
PROSITE
PS01351; MAPK
; 1; .
PROSITE
PS00107; PROTEIN_KINASE_ATP
; 1; .
PROSITE
PS50011; PROTEIN_KINASE_DOM
; 1; .
PROSITE
PS00108; PROTEIN_KINASE_ST
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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